Somatic glypican 3 (GPC3) mutations in Wilms' tumour

  • Br J Cancer. 2002 Jun 17;86(12):1920-2. doi: 10.1038/sj.bjc.6600417.
G R M White  1 ,  A M Kelsey ,  J M Varley ,  J M Birch
Affiliations
  • 1. Cancer Research UK Cancer Genetics Group, Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, UK.
PMID: 12085187 DOI: 10.1038/sj.bjc.6600417
Abstract

Tumour and normal tissue from 41 male cases of Wilms' tumour were screened to determine the presence of sequence variants in the glypican 3 (GPC3) gene. Two non-conservative single base changes were present in tumour tissue only. These findings imply a possible role for GPC3 in Wilms' tumour development.