Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template

  • Bioorg Med Chem Lett. 2003 Jan 20;13(2):257-60. doi: 10.1016/s0960-894x(02)00881-8.
John P Mogensen  1 ,  Lone Jeppesen ,  Paul S Bury ,  Ingrid Pettersson ,  Jan Fleckner ,  Jan Nehlin ,  Klaus S Frederiksen ,  Tatjana Albrektsen ,  Nanni Din ,  Steen B Mortensen ,  L Anders Svensson ,  Karsten Wassermann ,  Erik M Wulff ,  Lars Ynddal ,  Per Sauerberg
Affiliations
PMID: 12482434 DOI: 10.1016/s0960-894x(02)00881-8
Abstract

Using a known dual PPARalpha/gamma activator (5) as a structural template, SAR evaluations led to the identification of triple PPARalpha/gamma/delta activators (18-20) with equal potency and efficacy on all three receptors. These compounds could become useful tools for studying the combined biological effects of PPARalpha/gamma/delta activation.

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