Antiviral flavonoids from the root bark of Morus alba L

  • Phytochemistry. 2003 Apr;62(8):1235-8. doi: 10.1016/s0031-9422(02)00753-7.
Jiang Du  1 ,  Zhen-Dan He ,  Ren-Wang Jiang ,  Wen-Cai Ye ,  Hong-Xi Xu ,  Paul Pui-Hay But
Affiliations
  • 1. Department of Biology and Chemistry and Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, PR China.
PMID: 12648543 DOI: 10.1016/s0031-9422(02)00753-7
Abstract

A prenylated flavonoid, moralbanone, along with seven known compounds kuwanon S, mulberroside C, cyclomorusin, eudraflavone B hydroperoxide, oxydihydromorusin, leachianone G and alpha-acetyl-amyrin were isolated from the root bark of Morus alba L. Leachianone G showed potent Antiviral activity (IC(50) = 1.6 microg/ml), whereas mulberroside C showed weak activity (IC(50) = 75.4 microg/ml) against herpes simplex type 1 virus (HSV-1). Their structures were elucidated by spectroscopic methods.

Products