Simultaneous detection of some drugs of abuse in saliva samples by SPME technique

  • Forensic Sci Int. 2003 Jun 24;134(1):40-5. doi: 10.1016/s0379-0738(03)00098-7.
Nadia Fucci  1 ,  Nadia De Giovanni ,  Marcello Chiarotti
Affiliations
  • 1. Laboratorio di Tossicologia Forense, Istituto di Medicina Legale e delle Assicurazioni, Università Cattolica del Sacro Cuore, L. go Francesco Vito, 00168-Rome, Italy. [email protected]
PMID: 12842356 DOI: 10.1016/s0379-0738(03)00098-7
Abstract

A simple method for the simultaneous determination of many drugs of abuse in saliva is referred [methadone, 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium perchlorate (EDDP), cocaine, cocaethylene, amphetamine, methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyethyl amphetamine (MDEA), N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB), cannabidiol (CBD), Delta(9)-tetrahydrocannabinol (THC), cannabinol (CBN)]. Head space-solid phase microextraction (HS-SPME) and direct immersion-solid phase microextraction (DI-SPME) followed by gas chromatographic/mass spectrometric analyses (GC/MS) were employed, and results obtained with both techniques are discussed. The method was validated testing reproducibility, sensitivity, linearity.

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