Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. Part 4: structure-activity relationships for substituents on the quinazoline moiety of 4-[4-(N-substituted(thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives

  • Bioorg Med Chem Lett. 2003 Sep 15;13(18):3001-4. doi: 10.1016/s0960-894x(03)00634-6.
Kenji Matsuno  1 ,  Takashi Seishi ,  Takao Nakajima ,  Michio Ichimura ,  Neill A Giese ,  Jin-Chen Yu ,  Shoji Oda ,  Yuji Nomoto
Affiliations
  • 1. Kyowa Hakko Kogyo Co., Ltd., Pharmaceutical Research Institute, Shimotogari 1188, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8731, Japan. [email protected]
PMID: 12941321 DOI: 10.1016/s0960-894x(03)00634-6
Abstract

Here, we investigated the structure-activity relationships of the 6,7-dimethoxyquinazoline moiety. With regard to exploration of positions and varieties of substituents on the quinazoline ring, 6,7-dialkoxy substitution was optimal. This study suggests the possibility of further modifications for this moiety.