De novo synthesis of two new cytotoxic tiazofurin analogues with modified sugar moieties

  • Bioorg Med Chem Lett. 2003 Oct 6;13(19):3167-70. doi: 10.1016/s0960-894x(03)00712-1.
Mirjana Popsavin  1 ,  Ljilja Torović ,  Vesna Kojić ,  Gordana Bogdanović ,  Sasa Spaić ,  Velimir Popsavin
Affiliations
  • 1. Department of Chemistry, Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia and Montenegro, Yugoslavia. [email protected]
PMID: 12951086 DOI: 10.1016/s0960-894x(03)00712-1
Abstract

A divergent synthesis of two novel tiazofurin analogues, 2-(3-deoxy-3-fluoro-beta-D-xylofuranosyl)thiazole-4-carboxamide (2) and 2-(3-acetamido-3-deoxy-beta-D-xylofuranosyl)thiazole-4-carboxamide (3), has been achieved starting from D-glucose. Both nucleoside analogues were evaluated for their in vitro cytotoxicity against several human leukaemia and solid tumour cell lines.