Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z), 11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity

  • Bioorg Med Chem Lett. 2003 Nov 3;13(21):3719-20. doi: 10.1016/j.bmcl.2003.08.005.
Y Krishna Reddy  1 ,  L Manmohan Reddy ,  Jorge H Capdevila ,  J R Falck
Affiliations
  • 1. Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9038, USA.
PMID: 14552765 DOI: 10.1016/j.bmcl.2003.08.005
Abstract

An asymmetric synthesis of 16-HETE, an endogenous inhibitor of neutrophil activity, was achieved in six steps from R-(-)-glycidyl benzyl ether in 28% overall yield.

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