A new synthesis of naphthyridinones and quinolinones: palladium-catalyzed amidation of o-carbonyl-substituted aryl halides

  • Org Lett. 2004 Jul 8;6(14):2433-5. doi: 10.1021/ol049165t.
Peter J Manley  1 ,  Mark T Bilodeau
Affiliations
  • 1. Department of Medicinal Chemistry, Merck and Co., Inc., P.O. Box 4, West Point, Pennsylvania 19486, USA. [email protected]
PMID: 15228297 DOI: 10.1021/ol049165t
Abstract

[reaction: see text] An alternative to the Friedlander condensation for the synthesis of naphthyridinones and quinolinones has been discovered. Palladium-catalyzed amidation of halo aromatics substituted in the ortho position by a carbonyl functional group or its equivalent with primary or secondary amides leads to the formation of substituted naphthyridinones and quinolinones.

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