New diterpenoids from the marine mangrove Bruguiera gymnorrhiza

  • J Nat Prod. 2004 Sep;67(9):1620-3. doi: 10.1021/np040062t.
Li Han  1 ,  Xueshi Huang ,  Isabel Sattler ,  Hans-Martin Dahse ,  Hongzheng Fu ,  Wenhan Lin ,  Susanne Grabley
Affiliations
  • 1. National Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China.
PMID: 15387677 DOI: 10.1021/np040062t
Abstract

Phytochemical investigation of the stem of Bruguiera gymnorrhiza yielded three new ent-kaurane Diterpenoids (1, 2, and 3) and one new ent-beyerane diterpenoid (4) together with nine known ent-kaurane Diterpenoids. All structures and the relative stereochemistry of the new compounds were determined by NMR spectroscopic studies. The absolute stereochemistry of 4 was determined by CD data. Some of the compounds showed moderate cytotoxic properties.