Cellular retinol-binding protein functions in the regulation of retinoid metabolism

  • Nutr Rev. 1992 Jul;50(7):197-9. doi: 10.1111/j.1753-4887.1992.tb01325.x.
G Wolf  1
Affiliations
  • 1. Department of Nutritional Sciences, University of California, Berkeley 94720.
PMID: 1641199 DOI: 10.1111/j.1753-4887.1992.tb01325.x
Abstract

A microsomal retinyl ester hydrolase from rat tissues is activated by apo-cellular retinol-binding protein, which thus regulates the availability of retinol either for binding to serum retinol-binding protein or for metabolic oxidation. Microsomal retinal synthesis was found to occur in rat tissues with holo-cellular retinol-binding protein as substrate. Retinal could be further oxidized to retinoic acid by a cytosolic fraction.