Potential cancer chemopreventive agents from Arbutus unedo

  • Nat Prod Res. 2006 Apr;20(4):327-34. doi: 10.1080/14786410500161205.
Esperanza J Carcache-Blanco  1 ,  Muriel Cuendet ,  Eun Jung Park ,  Bao-Ning Su ,  J Fausto Rivero-Cruz ,  Norman R Farnsworth ,  John M Pezzuto ,  A Douglas Kinghorn
Affiliations
  • 1. Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
PMID: 16644527 DOI: 10.1080/14786410500161205
Abstract

A phytochemical study of the petroleum ether and ethyl acetate extracts of the entire plant of Arbutus unedo led to the isolation of a new sterol, 7beta-hydroxystigmast-4-en-3-one (1), and nine known compounds of the flavan, steroid, and terpenoid types. The structure of 1 was determined by spectroscopic data interpretation in combination with molecular modeling calculations. The absolute stereochemistry of C-7 was assigned as S for compound 1 based on the obtained CD spectral data. Activity in the JB6 cell transformation assay was found for pomolic acid 3-acetate (4). All isolates obtained were evaluated in a cyclooxygenase-2 (COX-2) inhibition assay.

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