ent-Abietane diterpenoids from Isodon rubescens var. rubescens

  • Phytochemistry. 2007 Mar;68(5):616-22. doi: 10.1016/j.phytochem.2006.11.007.
Sheng-Xiong Huang  1 ,  Jian-Xin Pu ,  Wei-Lie Xiao ,  Li-Mei Li ,  Zhi-Ying Weng ,  Yan Zhou ,  Quan-Bin Han ,  Shu-Lin Peng ,  Li-Sheng Ding ,  Li-Guang Lou ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 17173940 DOI: 10.1016/j.phytochem.2006.11.007
Abstract

ent-Abietane Diterpenoids, hebeiabinins A-F (1-5), together with seven known Diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The Diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC(50) value of 0.91 microM against A549 cells.

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