Fluorescence, CD, and NMR studies on spantide, a bombesin and substance P antagonist

  • Biopolymers. 1991 May;31(6):643-52. doi: 10.1002/bip.360310609.
C Di Bello  1 ,  A Scatturin ,  G D'Auria ,  M Gargiulo ,  L Paolillo ,  E Trivellone ,  R De Castiglione
Affiliations
  • 1. Institute of Industrial Chemistry, University of Padova, Italy.
PMID: 1718471 DOI: 10.1002/bip.360310609
Abstract

The conformational properties of spantide [(D-Arg, D-Trp, Leu) substance P] have been studied by fluorescence, CD, and nmr techniques. The fluorescence, CD, and nmr parameters in different Solvents and in a micellar environment (SDS) are compared with the data collected for bombesin. A preliminary investigation on [D-Pro] spantide is also reported.

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