Synthesis and evaluation of N-acetyl-L-tyrosine based compounds as PPARalpha selective activators

  • Eur J Med Chem. 2007 Apr;42(4):503-10. doi: 10.1016/j.ejmech.2006.11.005.
Rakesh Kumar  1 ,  Uma Ramachandran ,  Suryaprakash Raichur ,  Ranjan Chakrabarti ,  Rahul Jain
Affiliations
  • 1. Department of Pharmaceutical Technology, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160 062, India.
PMID: 17187904 DOI: 10.1016/j.ejmech.2006.11.005
Abstract

The development of type 2 diabetes in obese individuals is linked to lipid accumulation in non-adipose tissues. A series of N-acetyl-L-tyrosine derivatives were synthesized and evaluated for PPAR transactivation. Compounds 4d and 4f were found to show better PPARalpha transactivation as compared to PPARgamma. Molecular docking analysis was carried out to study their important interactions with the active site of PPARalpha.

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