The LT beta R signaling pathway

  • Adv Exp Med Biol. 2007;597:160-72. doi: 10.1007/978-0-387-70630-6_13.
Paula S Norris  1 ,  Carl F Ware
Affiliations
  • 1. Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA.
PMID: 17633025 DOI: 10.1007/978-0-387-70630-6_13
Abstract

The lymphotoxin-beta receptor (LTbetaR, TNFRSF3) signaling pathway activates gene transcription programs and cell death important in immune development and host defense. The TNF Receptor associated factors (TRAF)-2, 3 and 5 function as adaptors linking LTbetaR signaling targets. Interestingly, TRAF deficient mice do not phenocopy mice deficient in components of the LTbetaR pathway, presenting a conundrum. Here, an update of our understanding and models of the LTbetaR signaling pathway are reviewed, with a focus on this conundrum.

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