Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activities

  • Org Biomol Chem. 2007 Dec 21;5(24):3979-86. doi: 10.1039/b713060k.
Takeshi Yamada  1 ,  Masashi Iritani ,  Hirohumi Ohishi ,  Kayo Tanaka ,  Katsuhiko Minoura ,  Mitsunobu Doi ,  Atsushi Numata
Affiliations
  • 1. Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan.
PMID: 18043803 DOI: 10.1039/b713060k
Abstract

Pericosines A-E 1-5 have been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai. Among them, pericosines C 3 and E 5 were separated as enantiomeric mixtures. Their stereostructures, except for compound 1, have been elucidated or identified on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, and X-ray analysis. In addition, conformation for all the compounds has been discussed. Compounds 1-3 exhibited significant growth inhibition against tumour cell lines. Pericosine A 1 also showed significant in vivo tumour inhibitory activity. In addition, compound inhibited the protein kinase EGFR and Topoisomerase II.

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