Anti-infective and cytotoxic compounds present in Blepharodon nitidum

  • Planta Med. 2008 Mar;74(4):407-10. doi: 10.1055/s-2008-1034330.
José C Aponte  1 ,  Yannick Estevez ,  Robert H Gilman ,  Walter H Lewis ,  Rosario Rojas ,  Michel Sauvain ,  Abraham J Vaisberg ,  Gerald B Hammond
Affiliations
  • 1. Department of Chemistry, University of Louisville, Louisville, KY, U.S.A.
PMID: 18484532 DOI: 10.1055/s-2008-1034330
Abstract

A pharmacological screening of the ethanol extract and fractions of Blepharodon nitidum led to the isolation of fourteen compounds, two of which, 24-hydroperoxycycloart-25-en-3beta-ol and 25-hydroperoxycycloart-23-en-3beta-ol, exhibited in vitro anti- Mycobacterium tuberculosis and antileishmanial activities, as well as significant cytotoxic activity against a panel of human tumor cell lines.

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