Ambuic acid and torreyanic acid derivatives from the endolichenic fungus Pestalotiopsis sp

  • J Nat Prod. 2009 Jan;72(1):182-6. doi: 10.1021/np800733y.
Gang Ding  1 ,  Yan Li ,  Shaobin Fu ,  Shuchun Liu ,  Jiangchun Wei ,  Yongsheng Che
Affiliations
  • 1. Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.
PMID: 19117486 DOI: 10.1021/np800733y
Abstract

Six new ambuic acid (1) derivatives (2-7) and a new torreyanic acid analogue (8) have been isolated from the crude extract of endophytic fungus Pestalotiopsis sp. inhabiting the Lichen Multiclavula [corrected] sp. The structures of these compounds were elucidated primarily by NMR and MS methods, and their absolute configurations were assigned by application of the CD excitation chirality method. Compounds 1 and 2 displayed antimicrobial activity against the Gram-positive bacterium Staphylococcus aureus.

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