Cytotoxic prenylated flavonoids from the stem bark of Maackia amurensis

  • Chem Pharm Bull (Tokyo). 2009 Mar;57(3):302-6. doi: 10.1248/cpb.57.302.
Xiong Li  1 ,  Dong Wang ,  Ming-Yu Xia ,  Zhi-Hui Wang ,  Wei-Ning Wang ,  Zheng Cui
Affiliations
  • 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
PMID: 19252325 DOI: 10.1248/cpb.57.302
Abstract

Five new prenylated Flavonoids, maackiaflavanone A (1), maackiaflavanone B (2), maackiapentone (3), maackiapterocarpan A (4), maackiapterocarpan B (5) along with eleven known Flavonoids were isolated from the stem bark of Maackia amurensis. The structures of the new compounds were elucidated by spectroscopic methods. The cytotoxicities of compounds 1-4, 6, 8-12 and 14-16 against four human Cancer cell lines, A375S2, HeLa, MCF-7 and HepG2, were tested by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Among the compounds tested, compound 2 showed the strongest cytotoxic activity with IC(50) value of 7.8 microM against A375S2 and euchrenone b(1) showed the most potent cytotoxicity with IC(50) value of 4.5 microM against HeLa.

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