Structural determination of aspericins A-C, new furan and pyran derivates from the marine-derived fungus Rhizopus sp. 2-PDA-61, by 1D and 2D NMR spectroscopy

  • Magn Reson Chem. 2010 Feb;48(2):155-8. doi: 10.1002/mrc.2545.
Fazuo Wang  1 ,  Tianjiao Zhu ,  Min Zhang ,  Aiqun Lin ,  Weiming Zhu ,  Qianqun Gu
Affiliations
  • 1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, P. R. China.
PMID: 19937604 DOI: 10.1002/mrc.2545
Abstract

Three new furan and pyran derivatives named aspericins A-C (1-3), as well as a known asperic acid (4), have been isolated from the marine-derived fungus Rhizopus sp. 2-PDA-61. The complete (1)H and (13)C NMR assignments for the new compounds were carried out using (1)H, (13)C, DEPT, COSY, HMQC, HMBC, and NOESY NMR experiments. Compounds 1-3 were evaluated for their cytotoxic activities on P388, A549, HL-60, and BEL-7420 cell lines by the MTT and SRB methods.

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