Gentisides A and B, two new neuritogenic compounds from the traditional Chinese medicine Gentiana rigescens Franch

  • Bioorg Med Chem. 2010 Mar 15;18(6):2131-2134. doi: 10.1016/j.bmc.2010.02.004.
Lijuan Gao  1 ,  Jinyou Li ,  Jianhua Qi
Affiliations
  • 1. College of Pharmaceutical Sciences, Zhejiang University, Yu Hang Tang Road 388, Hangzhou 310058, China.
PMID: 20189814 DOI: 10.1016/j.bmc.2010.02.004
Abstract

Two new alkyl 2,3-dihydroxybenzoates, gentisides A and B, were isolated from the traditional Chinese medicine Gentiana rigescens Franch. Their structures and stereochemistry were elucidated by spectroscopic methods and chemical derivatization. These compounds showed a significant neuritogenic activity at 30 microM against PC12 cells that was comparable to that seen for the best nerve growth factor (NGF) concentration of 40 ng/mL. Gentisides A and B showed parallel activity, indicating that the observed structural difference at the end of their alkyl chain did not affect neuritogenic activity.

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