Pterosins from Pteris multifida

  • Planta Med. 2010 Nov;76(16):1896-900. doi: 10.1055/s-0030-1249934.
Dan-Wei Ouyang  1 ,  Xiang Ni ,  Hai-Yan Xu ,  Jia Chen ,  Pei-Ming Yang ,  De-Yun Kong
Affiliations
  • 1. Department of Chinese Traditional Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, P R China.
PMID: 20486077 DOI: 10.1055/s-0030-1249934
Abstract

A new C(14) pterosin sesquiterpenoid, named (2R)-pterosin P (1), and a new natural product, named dehydropterosin B (3), were isolated from the aerial parts of Pteris multifida Poir., along with nine known compounds (2, 4-11). By chiral HPLC, compounds 1 and 2 were isolated as a pair of enantiomeric pterosin sesquiterpenoids. The planar structure of 1 was elucidated on the basis of NMR spectroscopy analysis, and the absolute configuration was established by the CD spectrum. In addition, the absolute structure of 1 was further confirmed by single-crystal X-ray diffraction (CuK α). Compounds 3, 5, and 6 showed potent cytotoxicity against PANC-1 (human pancreatic Cancer) and NCI-H446 (human small-cell lung Cancer) cell lines, with IC(50) values in the range of 4.27-14.63 µM.

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