Cytotoxic prenylated flavonoids from Morus alba

  • Fitoterapia. 2010 Dec;81(8):1224-7. doi: 10.1016/j.fitote.2010.08.006.
Nguyen Tien Dat  1 ,  Phung Thi Xuan Binh ,  Le Thi Phuong Quynh ,  Chau Van Minh ,  Hoang Thanh Huong ,  Jung Joon Lee
Affiliations
  • 1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, Vietnam.
PMID: 20727950 DOI: 10.1016/j.fitote.2010.08.006
Abstract

A phytochemical fractionation of the methanol extract of the Morus alba leaves led to the isolation of eleven Flavonoids (1-11). The structure of the new 3'-geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone (1) was elucidated by means of spectroscopic methods. The cytotoxicity of the isolated compounds against human cervical carcinoma HeLa, human breast carcinoma MCF-7, and human hepatocarcinoma Hep3B cells was evaluated. Of note, morusin (9) was the most potent with an IC(50) value of 0.64 μM against HeLa cells.

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