Synthesis and biological evaluation of benzo[d]imidazole derivatives as potential anti-cancer agents

  • Bioorg Med Chem Lett. 2012 Feb 1;22(3):1317-21. doi: 10.1016/j.bmcl.2011.12.088.
Hamad M Alkahtani  1 ,  Abdullahi Y Abbas ,  Shudong Wang
Affiliations
  • 1. School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK.
PMID: 22225635 DOI: 10.1016/j.bmcl.2011.12.088
Abstract

We herein report the synthesis, biological activity and structure-activity relationship of derivatives of 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole and benzo[d]imidazole. A lead compound 6o demonstrates potent anti-proliferative activity and the ability to induce Cancer cell Apoptosis.