Khayseneganins A-H, limonoids from Khaya senegalensis

  • J Nat Prod. 2013 Mar 22;76(3):327-33. doi: 10.1021/np3006919.
Chun-Mao Yuan  1 ,  Yu Zhang ,  Gui-Hua Tang ,  Ying-Tong Di ,  Ming-Ming Cao ,  Xiao-Ying Wang ,  Guo-Ying Zuo ,  Shun-Lin Li ,  Hui-Ming Hua ,  Hong-Ping He ,  Xiao-Jiang Hao
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
PMID: 23210623 DOI: 10.1021/np3006919
Abstract

Eight new limonoids, khayseneganins A-H (1-8), and 31 known limonoids were isolated from the leaves and twigs of Khaya senegalensis. The structures of the new compounds were elucidated by 2D-NMR spectroscopy and mass spectrometry, and the absolute configuration of 1 was determined by the CD exciton chirality method. Compounds 9, 10, 12, and 15 showed antimicrobial activities against Pseudomonas aeruginosa, MRSA 92(#), and MRSA 98(#), all with a MIC value of 12.5 μg/mL.

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