Novel NGF-potentiating limonoids from the fruits of Melia toosendan

  • Fitoterapia. 2013 Oct:90:192-8. doi: 10.1016/j.fitote.2013.07.019.
Qiong Zhang  1 ,  Jian-Kuan Li ,  Rui Ge ,  Jing-Yu Liang ,  Qing-Shan Li ,  Zhi-Da Min
Affiliations
  • 1. Department of Pharmaceutical Science, Shanxi Medical University, No.56 Xinjian South Road, Taiyuan 030001, Shanxi, PR China. Electronic address: [email protected].
PMID: 23916581 DOI: 10.1016/j.fitote.2013.07.019
Abstract

Four new limonoids (1-4), together with five known limonoids (5-9), were isolated from the fruits of Melia toosendan. Their structures were elucidated based on extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, IR, [α](D)). The isolated compounds were evaluated for their neurite outgrowth-promoting activities. Compounds 2 and 6 significantly enhanced NGF-mediated neurite outgrowth in PC12 cells at concentrations ranging from 0.1 to 50.0 μM.

Keywords
Limonoid; Melia toosendan; Meliaceae; Neurite outgrowth-promoting activity; Nimbolinin.
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