Gusperimus: immunological mechanism and clinical applications

  • Rheumatology (Oxford). 2014 Oct;53(10):1732-41. doi: 10.1093/rheumatology/ket451.
Miklos Perenyei  1 ,  David R W Jayne  1 ,  Oliver Floßmann  2
Affiliations
  • 1. Medical Sciences Division, University of Oxford, Oxford, Lupus and Vasculitis Clinic, Addenbrookes Hospital, Cambridge and Department of Nephrology, Royal Berkshire Hospital, Reading, UK.
  • 2. Medical Sciences Division, University of Oxford, Oxford, Lupus and Vasculitis Clinic, Addenbrookes Hospital, Cambridge and Department of Nephrology, Royal Berkshire Hospital, Reading, UK. [email protected].
PMID: 24501242 DOI: 10.1093/rheumatology/ket451
Abstract

Gusperimus is an immunosuppressive drug with a unique mode of action. We review its effects on different arms of the immune system and the current evidence for clinical applications, particularly in the treatment of transplant rejection and ANCA-associated vasculitis.

Keywords
deoxyspergualin; glomerulonephritis; gusperimus; immune suppressant; rejection; systemic lupus erythematosus; transplantation; vasculitis.
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