Cyclic lipodepsipeptides verlamelin A and B, isolated from entomopathogenic fungus Lecanicillium sp

  • J Antibiot (Tokyo). 2014 Jun;67(6):459-63. doi: 10.1038/ja.2014.22.
Kei-Ichi Ishidoh  1 ,  Hiroshi Kinoshita  1 ,  Yasuhiro Igarashi  2 ,  Fumio Ihara  3 ,  Takuya Nihira  4
Affiliations
  • 1. International Center for Biotechnology, Osaka University, Osaka, Japan.
  • 2. Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan.
  • 3. National Institute of Fruit Tree Science, Ibaraki, Japan.
  • 4. 1] International Center for Biotechnology, Osaka University, Osaka, Japan [2] Mahidol University-Osaka University Collaborative Research Center for Bioscience and Biotechnology, Faculty of Science, Mahidol University, Bangkok, Thailand.
PMID: 24690913 DOI: 10.1038/ja.2014.22
Abstract

Verlamelin and its new derivative (verlamelin B) were isolated from fermentation broth of entomopathogenic fungus Lecanicillium sp. HF627. As the structural elucidation of verlamelin so far was only preliminary, we studied and determined the absolute structure of these two compounds to be cyclo(5S-hydroxytetradecanoic acid-D-alloThr/Ser-D-Ala-L-Pro-L-Gln-D-Tyr-L-Val). This is the first study that precisely analyzed the structure of verlamelin.

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