Cytotoxicity studies of semi-synthetic derivatives of theveside derived from the aqueous extract of leaves of 'suicide tree' Cerbera odollam

  • Nat Prod Res. 2014;28(18):1507-12. doi: 10.1080/14786419.2014.913242.
Jaggaiah N Gorantla  1 ,  Jamsheena Vellekkatt ,  Lekshmi R Nath ,  Ruby John Anto ,  Ravi S Lankalapalli
Affiliations
  • 1. a Academy of Scientific and Innovative Research (AcSIR) , New Delhi 110 001 , India.
PMID: 24805359 DOI: 10.1080/14786419.2014.913242
Abstract

We report the isolation of two known iridoid glucosides theviridoside (1) and theveside (2) from the aqueous extract of leaves of Cerbera odollam and semi-synthetic derivatisation of theveside prepared in a single step under protection group-free conditions. Derivatives 2a-j were evaluated for cytotoxicity towards five human Cancer cell lines of different origins, namely SKBR3 (breast), HeLa (cervical), A375 (skin), HepG2 (liver) and HCT-116 (colon), and IC50 values were determined. Derivatives 2b and 2h exhibited moderate cytotoxicity against HCT-116 and A375 cell lines, respectively.

Keywords
Cerbera odollam; cytotoxicity; semi-synthetic derivatives; theveside; theviridoside.
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