Mitotic kinesins: a reason to delve into kinesin-12

  • Curr Biol. 2014 Oct 6;24(19):R968-70. doi: 10.1016/j.cub.2014.09.011.
William O Hancock  1
Affiliations
  • 1. Department of Biomedical Engineering, Pennsylvania State University, 229 Hallowell Building, Pennsylvania State University, University Park, PA, USA. Electronic address: [email protected].
PMID: 25291641 DOI: 10.1016/j.cub.2014.09.011
Abstract

The failure of kinesin-targeting Cancer drugs is thought to result from functional redundancy of mitotic kinesins. A new study provides mechanistic insights into Kinesin-12 that help to explain its targeting to kinetochore fibers and its ability to compensate for inhibition of kinesin-5.