Teucrium polium phenylethanol and iridoid glycoside characterization and flavonoid inhibition of biofilm-forming Staphylococcus aureus

  • J Nat Prod. 2015 Jan 23;78(1):2-9. doi: 10.1021/np5004092.
Wael A Elmasri  1 ,  Tianjiao Yang ,  Phat Tran ,  Mohamed-Elamir F Hegazy ,  Abdul N Hamood ,  Yehia Mechref ,  Paul W Paré
Affiliations
  • 1. Department of Chemistry and Biochemistry, Texas Tech University , Lubbock, Texas 79409, United States.
PMID: 25524452 DOI: 10.1021/np5004092
Abstract

The chemical composition and biofilm regulation of 15 metabolites from Teucrium polium are reported. Compounds were isolated from a CH2Cl2-MeOH extract of the aerial parts of the plant and included iridoid and phenylethanol glycosides and a monoterpenoid, together with nine known compounds. The structures were elucidated based on standard spectroscopic (UV, (1)H and (13)C NMR), 2D NMR ((1)H-(1)H COSY, HMQC, HMBC, and NOESY), and/or LC-ESIMS/MS data analyses. Inhibition of the biofilm-forming strain Staphylococcus aureus was observed with exposure to compounds 7 and 8.

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