Two new diterpenes from the seeds of Caesalpinia minax Hance

  • J Asian Nat Prod Res. 2015;17(9):893-9. doi: 10.1080/10286020.2015.1039998.
Lian Lian  1 ,  Xiao-Bin Li  2 ,  Jiu-Zhi Yuan  2 ,  Li Cheng  2 ,  Zhao-Hua Wu  2 ,  Hui-Yuan Gao  3
Affiliations
  • 1. a School of Biopharmaceutical and Chemical Engineering, Liaoning Institute of Science and Technology , Benxi 117004 , China.
  • 2. b School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • 3. c Department of Pharmacology , Mudanjiang Medical College , Mudanjiang 157001 , China.
PMID: 26274809 DOI: 10.1080/10286020.2015.1039998
Abstract

Molecules with diterpene skeletons often possess valuable medicinal properties. Two new diterpenes 1α,6α,7β-triacetoxy-5α-hydroxy-14β-ethyl-O-vouacapane (1) and 2α-acetoxy-14,15-cyclopimara-7β,16-diol (2) were isolated from the seeds of Caesalpinia minax Hance. Their structures were established on the basis of extensive spectroscopic analyses, including HR-ESI-MS, UV, IR, 1D, and 2D NMR (HSQC, HMBC, NOESY) methods. The stereochemical structure of 1 was confirmed via the circular dichroism spectrum and calculated ECD experiment. The inhibitory activity of nitric oxide production of RAW264.7 Macrophages stimulated by lipopolysaccharide of compounds 1 and 2 was evaluated, and compound 1 was found to show significant inhibitory effect.

Keywords
Caesalpinia minax; anti-inflammation; circular dichroism; diterpenes.
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