Long Noncoding RNAs in Cancer Pathways

  • Cancer Cell. 2016 Apr 11;29(4):452-463. doi: 10.1016/j.ccell.2016.03.010.
Adam M Schmitt  1 ,  Howard Y Chang  2
Affiliations
  • 1. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: [email protected].
  • 2. Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: [email protected].
PMID: 27070700 DOI: 10.1016/j.ccell.2016.03.010
Abstract

Genome-wide Cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many important Cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein, and RNA. Recent advancements in surveying lncRNA molecular mechanisms are now providing the tools to functionally annotate these cancer-associated transcripts, making these molecules attractive targets for therapeutic intervention in the fight against Cancer.