Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?

  • Mol Cell Oncol. 2015 Jan 30;2(3):e995047. doi: 10.4161/23723556.2014.995047.
Marcus Conrad  1 ,  José Pedro Friedmann Angeli  1
Affiliations
  • 1. Institute of Developmental Genetics; Helmholtz Zentrum München; , München, Germany.
PMID: 27308484 DOI: 10.4161/23723556.2014.995047
Abstract

The system XC (-)/glutathione/Glutathione Peroxidase 4 (GPX4) axis pivotally controls Ferroptosis, a recently described form of regulated non-apoptotic cell death. Compelling evidence has established that this route of cell death is not only of high relevance for triggering Cancer cell death, but also proves to be amenable for therapeutic intervention to halt ischemia/reperfusion-related diseases.

Keywords
cell death; lipid peroxidation; non-apoptotic cell death; regulated necrosis.