Antiplasmodial alkaloids from bulbs of Amaryllis belladonna Steud

  • Bioorg Med Chem Lett. 2018 Jan 1;28(1):40-42. doi: 10.1016/j.bmcl.2017.11.021.
Namki Cho  1 ,  Yongle Du  1 ,  Ana Lisa Valenciano  2 ,  Maria L Fernández-Murga  3 ,  Michael Goetz  4 ,  Jason Clement  4 ,  Maria B Cassera  2 ,  David G I Kingston  5
Affiliations
  • 1. Department of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA 24061, United States.
  • 2. Department of Biochemistry and Molecular Biology, and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, GA 30602, United States.
  • 3. Department of Biochemistry, M/C 0308, Virginia Tech, Blacksburg, VA 24061, United States.
  • 4. Natural Products Discovery Institute, 3805 Old Easton Road, Doylestown, PA 18902, United States.
  • 5. Department of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA 24061, United States. Electronic address: [email protected].
PMID: 29162457 DOI: 10.1016/j.bmcl.2017.11.021
Abstract

A bioassay-guided fractionation and chemical investigation of Amaryllis belladonna Steud. bulbs resulted in the isolation and identification of the new crinane alkaloid 1,4-dihydroxy-3-methoxy powellan (1), along with the 3 known crinane Alkaloids 2-4 and the two lycorane Alkaloids 5-6. The structures were elucidated by interpretation of combined HR-ESIMS, CD and 2D NMR spectroscopic data. Among these isolated compounds the lycorane-type alkaloid acetylcaranine (5) exhibited strong antiplasmodial activity, while compounds 3 and 4 were moderately active, and compounds 1 and 6 were inactive.

Keywords
Amaryllis belladonna; Antiplasmodial; Bioassay-guided; Crinane; Lycorine.
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