A short non-cytotoxic antimicrobial peptide designed from Aβ29-40 adopts a nanostructure and shows in vivo anti-endotoxin activity

  • Chem Commun (Camb). 2017 Dec 5;53(97):13079-13082. doi: 10.1039/c7cc07547b.
Munesh Kumar Harioudh  1 ,  Rohit Sahai ,  Kalyan Mitra ,  Jimut Kanti Ghosh
Affiliations
  • 1. Molecular and Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow-226031, Uttar Pradesh, India. [email protected].
PMID: 29168511 DOI: 10.1039/c7cc07547b
Abstract

Aβ29-40 residues with tryptophan in place of the lone methionine residue and three arginine residues added to its C-terminus exhibited augmented Antibacterial activities and protected mice against a lethal dose of LPS. The results show the conversion of a Aβ29-40 segment into a cell-selective antimicrobial/anti-endotoxin peptide with nanostructure and cation-π interaction.

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