New hepatoprotective isoflavone glucosides from Pueraria lobata (Willd.) Ohwi

  • Nat Prod Res. 2019 Dec;33(24):3485-3492. doi: 10.1080/14786419.2018.1484461.
Yingjie Sun  1  2 ,  Hongmin Zhang  1  2 ,  Ming Cheng  1  2 ,  Shijie Cao  1 ,  Miao Qiao  1  2 ,  Boli Zhang  1 ,  Liqin Ding  1 ,  Feng Qiu  1  2
Affiliations
  • 1. Tianjin State Key Laboratory of Modern Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin , P.R. China.
  • 2. School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine , Tianjin , P.R. China.
PMID: 29968479 DOI: 10.1080/14786419.2018.1484461
Abstract

Two new isoflavone glucosides, 3'-methoxyneopuerarin A (1) and 3'-methoxyneopuerarin B (2), together with nine known Isoflavones including puerarin (3), neopuerarin A (4), neopuerarin B (5), daidzin (6), daidzein (7), 3'-methoxypuerarin (PG-3) (8), puerarin xyloside (9), mirificin (10), 3'-hydroxypuerarin (11) were isolated from the water extraction of the dried roots of Pueraria lobata (Willd.) Ohwi. Their structures were elucidated by the means of spectroscopic and chromatographic analysis methods. All compounds were evaluated for their hepatoprotective activity on HepG2 cells. All of them showed statistically significant hepatoprotective effect.

Keywords
(Willd.) Ohwi; hepatoprotective effect; isoflavone.
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