Modulation of receptor mediated leukotriene release in the perfused heart

  • Gen Pharmacol. 1986;17(4):437-40. doi: 10.1016/0306-3623(86)90187-4.
A M Lefer ,  D M Roth ,  J L Kugler ,  J B Smith
PMID: 3019823 DOI: 10.1016/0306-3623(86)90187-4
Abstract

The chemotactic peptide n-formyl-methionyl-leucyl-phenylalanine (FMLP) induces peptide leukotriene release at concentrations of 20-25 pmol/ml 3 min after the start of FMLP infusion. FMLP-induced leukotriene release in rabbit Hearts is not blocked by the Leukotriene Receptor antagonist FPL-55712 at concentrations that totally antagonize the hemodynamic effects of exogenously infused peptide Leukotrienes. Moreover, propyl gallate, a Lipoxygenase inhibitor, does not block FMLP-induced leukotriene release. However, the chemotactic peptide antagonist (Boc-Phe-Leu-Phe-Leu-Phe-OH) totally antagonized FMLP-induced leukotriene release suggesting that the release is via a different mechanism, possibly a receptor mediated event.

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