Cytotoxic Tigliane Diterpenoids from Croton damayeshu

  • J Nat Prod. 2019 Jun 28;82(6):1550-1557. doi: 10.1021/acs.jnatprod.9b00042.
Jiao-Jiao Cui  1  2 ,  Kai-Long Ji  1 ,  Hong-Chun Liu  1 ,  Bin Zhou  1 ,  Qun-Fang Liu  1 ,  Cheng-Hui Xu  1 ,  Jian Ding  1 ,  Jin-Xin Zhao  1 ,  Jian-Min Yue  1  2
Affiliations
  • 1. State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Shanghai 201203 , People's Republic of China.
  • 2. University of Chinese Academy of Sciences , No. 19A Yuquan Road , Beijing 100049 , People's Republic of China.
PMID: 31117522 DOI: 10.1021/acs.jnatprod.9b00042
Abstract

Chemical investigation of an EtOH extract of the twigs and leaves of Croton damayeshu afforded 10 new tigliane Diterpenoids, crodamoids A-J (1-10), along with five known compounds. Their structures were elucidated by physical data analysis. Compounds 8, 9, and 15 displayed cytotoxic effects against two human tumor cell lines, A549 and HL-60 (IC50: 0.9-2.4 μM).