Bioactive glycosides from Salacia cochinchinensis

  • Carbohydr Res. 2019 Oct 1:484:107777. doi: 10.1016/j.carres.2019.107777.
Hui-Mei You  1 ,  Jia-Wen Zhao  1 ,  Yu-Xing Jing  1 ,  Juan-Rong Zhang  1 ,  Wei Wang  1 ,  Yun-Tao Jiang  1 ,  Ai-Xue Zuo  2 ,  Jun-Ting Fan  3 ,  Li-Zhu Zhang  1 ,  Min Zhou  1 ,  Zhi-Yong Jiang  4
Affiliations
  • 1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Chenggong New District, Kunming, Yunnan, 650500, China.
  • 2. Yunnan University of Traditional Chinese Medicine, Chenggong New District, Kunming, Yunnan, 650500, China.
  • 3. Department of Pharmceutical Analysis, School of Pharmcy, Nanjing Medical University, Nanjing, 211166, China.
  • 4. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Chenggong New District, Kunming, Yunnan, 650500, China. Electronic address: [email protected].
PMID: 31446303 DOI: 10.1016/j.carres.2019.107777
Abstract

Four new triterpene glycosides, named salaciacochinosides A-D (1-4) were isolated from the 90% ethanol extract of Salacia cochinchinensis, together with five known compounds 2α,3β,23-trihydroxyurs-12,18-dien-28-oic acid 28-O-β-d-glucopyranoside (5), racemiside (6), alangiplatanoside (7), acantrifoside E (8), and syringin (9). The structures of the four new triterpenoids were characterized by chemical methods and MS, IR, 1D and 2D NMR spectral analyses. The α-glucosidase inhibitory activities of the nine compounds were assessed, compounds 6 and 7 showed remarkable α-glucosidase inhibitory activities, with IC50 values of 0.44 and 0.75 μM, respectively. Compounds 1-5 exhibited moderate α-glucosidase inhibitory activities, and compounds 8 and 9 showed none α-glucosidase inhibitory activity in our current experiments.

Keywords
Salacia cochinchinensis; Salaciacochinosides A-D; Triterpene glycosides; α-glucosidase.
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