IGF-1C domain-modified chitosan hydrogel accelerates cutaneous wound healing by promoting angiogenesis

  • Future Med Chem. 2020 Jul;12(13):1239-1251. doi: 10.4155/fmc-2020-0071.
Qiong Li  1 ,  Jian Cui  2 ,  Haoyan Huang  3 ,  Zhiwei Yue  3 ,  Yuqiao Chang  1 ,  Nana Li  1 ,  Zhibo Han  4  5 ,  Zhong-Chao Han  4  5 ,  Zhikun Guo  1 ,  Zongjin Li  1  3
Affiliations
  • 1. Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, China.
  • 2. Department of Intensive Care Unit (ICU), People's Hospital of Rizhao, Rizhao, Shandong, China.
  • 3. Nankai University School of Medicine, Tianjin, China.
  • 4. Tianjin Key Laboratory of Engineering Technologies for Cell Pharmaceutical, National Engineering Research Center of Cell Products, AmCellGene Co., Ltd, Tianjin China.
  • 5. Jiangxi Engineering Research Center for Stem Cell, Shangrao, Jiangxi, China.
PMID: 32351127 DOI: 10.4155/fmc-2020-0071
Abstract

Background: Complete regeneration after skin injury remains a critical clinical challenge. Hydrogels, modified with growth factors or mimicking Peptides, have been applied for functional tissue regeneration by increasing the bioactivity of engineered matrices. Methodology & results: We synthesized an injectable biological hydrogel, C domain of IGF-1 (IGF-1C)-modified chitosan (CS-IGF-1C) hydrogel. Mouse model of cutaneous wound healing was established to investigate whether this hydrogel could promote wound healing. Our results demonstrated that CS-IGF-1C hydrogel exhibited superior proangiogenic effects, resulting in accelerated wound closure and improved extracellular matrix remodeling. Bioluminescence imaging and histology analysis confirmed the proangiogenic role of CS-IGF-1C hydrogel. Conclusion: CS-IGF-1C hydrogel could accelerate cutaneous wound healing by stimulating angiogenesis.

Keywords
C domain of IGF-1; angiogenesis; hydrogel; remodeling; wound healing.
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