Immune modulating effects of receptor interacting protein 2 (RIP2) in autoinflammation and immunity

  • Clin Immunol. 2021 Feb;223:108648. doi: 10.1016/j.clim.2020.108648.
Sigrun Ruth Hofmann  1 ,  Leonie Girschick  2 ,  Robert Stein  2 ,  Felix Schulze  2
Affiliations
  • 1. Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Electronic address: [email protected].
  • 2. Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
PMID: 33310070 DOI: 10.1016/j.clim.2020.108648
Abstract

Receptor-interacting protein 2 (RIP2) is a kinase that is involved in downstream signaling of nuclear oligomerization domain (NOD)-like receptors NOD1 and 2 sensing Bacterial peptidoglycans. RIP2-deficiency or targeting of RIP2 by pharmaceutical inhibitors partially ameliorates inflammatory diseases by reducing pro-inflammatory signaling in response to peptidoglycans. However, RIP2 is widely expressed and interacts with several Other proteins suggesting additional functions outside the NOD-signaling pathway. In this review, we discuss the immunological functions of RIP2 and its possible role in autoinflammation and immunity.

Keywords
Apoptosis-associated speck-like protein containing a CARD (ASC); Caspase-1; IL-1β; Inflammasome; Interleukin-1 converting enzyme; NLRP3; NOD1; NOD2; RIPK2.