Thioridazine hydrochloride: an antipsychotic agent that inhibits tumor growth and lung metastasis in triple-negative breast cancer via inducing G0/G1 arrest and apoptosis

  • Cell Cycle. 2020 Dec;19(24):3521-3533. doi: 10.1080/15384101.2020.1850969.
Yanlin Song  1  2 ,  Lu Li  1 ,  Jiao Chen  1 ,  Hongli Chen  1 ,  Bomiao Cui  1 ,  Yun Feng  1 ,  Ping Zhang  1 ,  Qiangsheng Zhang  1 ,  Yong Xia  3  4 ,  Min Luo  1
Affiliations
  • 1. State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu, Sichuan, China.
  • 2. West China School of Medicine, West China Hospital, Sichuan University , Chengdu, Sichuan, China.
  • 3. Department of Rehabilitation Medicine, West China Hospital, Sichuan University , Chengdu, Sichuan, 610041, China.
  • 4. Key Laboratory of Rehabilitation Medicine, West China Hospital, Sichuan University , Chengdu Sichuan, 610041, China.
PMID: 33315498 DOI: 10.1080/15384101.2020.1850969
Abstract

CCK8: Cell Counting Kit-8; CDK: cyclin-dependent kinase; DRD2: dopamine D2 receptor; ERK1/2: extracellular signal-regulated kinase 1/2; GAPDH: glyceraldehyde 3-phosphate dehydrogenase; H&E: hematoxylin and eosin; MMP: membrane potential; NAC: N-acetyl-L-cysteine; PI: Propidium iodide; Rh123: rhodamine-123; ROS: reactive oxygen species; TBST: tris-buffered saline containing 0.1% Tween 20 TNBC: Triple-negative breast cancer; Thi-hyd: Thioridazine hydrochloride.

Keywords
PI3K/AKT pathway; Thioridazine hydrochloride; antipsychotic agent; triple-negative breast cancer.
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