Two new sesquiterpenes from Sonchus oleraceus and inhibitory mechanism on murine haemangioendothelioma (EOMA) cell lines

  • Nat Prod Res. 2022 Jun;36(11):2814-2820. doi: 10.1080/14786419.2021.1931186.
Mingming Lei  1 ,  Qi Wang  1 ,  Bing Liu  2 ,  Yuqin Che  3
Affiliations
  • 1. Department of Cardiovascular, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, P. R. China.
  • 2. College of Pharmacy, Harbin University of Commerce, Harbin, P.R. China.
  • 3. Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, P. R. China.
PMID: 34039229 DOI: 10.1080/14786419.2021.1931186
Abstract

Sonchus oleraceus is a kind of medicinal and edible plant which is widely distributed. In this study, two new Sesquiterpenes 1 and 2 along with three known compounds 3-5 were isolated from Sonchus oleraceus by the methods of column chromatography. The structures of the two novel compounds were constructed on the basis of HR-MS and NMR spectra. Cytotoxicities of 1 and 2 were assayed on EOMA cell lines and 1 exhibited no inhibitory effect while 2 elicited moderate inhibitory effect on EOMA cells with IC50 value of 26.5 μM. Western Blot assay indicated that 2 could suppress EOMA cell proliferation by inducing Apoptosis through Bax/Caspase-3 pathway.

Keywords
Asteraceae; Sonchus oleraceus; cytotoxicity; sesquiterpenes; western blot.
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