Single-cell RNA sequencing in pancreatic cancer

  • Nat Rev Gastroenterol Hepatol. 2021 Jul;18(7):451-452. doi: 10.1038/s41575-021-00471-z.
Jincheng Han  1 ,  Ronald A DePinho  1 ,  Anirban Maitra  2
Affiliations
  • 1. Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • 2. Department of Translational Molecular Pathology, The Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA. [email protected].
PMID: 34040169 DOI: 10.1038/s41575-021-00471-z
Abstract

The application of single-cell RNA Sequencing platforms has generated notable insights into the heterogeneity underlying Pancreatic Ductal Adenocarcinoma (PDAC), encompassing both the neoplastic compartment and the tumour microenvironment. In this Comment, we discuss the most pertinent findings gleaned from both mouse models and human PDAC samples, as well as future opportunities.