Adduct of Aquacobalamin with Hydrogen Peroxide

  • Inorg Chem. 2021 Sep 6;60(17):12681-12684. doi: 10.1021/acs.inorgchem.1c01483.
Maria Lehene  1 ,  Diana Plesa  1 ,  Stefania Ionescu-Zinca  1 ,  Stefania D Iancu  2 ,  Nicolae Leopold  2 ,  Sergei V Makarov  3 ,  Adrian M V Brânzanic  1 ,  Radu Silaghi-Dumitrescu  1
Affiliations
  • 1. Department of Chemistry, Babes-Bolyai University (BBU), Str. Arany Janos Nr. 11, RO-400028 Cluj-Napoca, Romania.
  • 2. Faculty of Physics, Babes-Bolyai University (BBU), Str. Kogalniceanu 1, RO-400084 Cluj-Napoca, Romania.
  • 3. Ivanovo State University of Chemistry and Technology, Sheremetevskiy Str. 7, 153000 Ivanovo, Russia.
PMID: 34382784 DOI: 10.1021/acs.inorgchem.1c01483
Abstract

Aquacobalamin binds hydrogen peroxide reversibly to form a cobalt(III) hydroperoxo adduct with a 0.25 mM dissociation constant, as evidenced by UV-vis absorption spectroscopy and corroborated by NMR, Raman spectroscopy, stopped-flow UV-vis measurements, and density functional theory calculations.

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