Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide

  • Cell Discov. 2024 Jul 17;10(1):77. doi: 10.1038/s41421-024-00700-0.
Wenzhuo Li  #  1  2  3 ,  Qingtong Zhou  #  4 ,  Zhaotong Cong  #  4 ,  Qingning Yuan  5 ,  Wenxin Li  4 ,  Fenghui Zhao  1  2 ,  H Eric Xu  3  5 ,  Li-Hua Zhao  6  7 ,  Dehua Yang  8  9  10  11 ,  Ming-Wei Wang  12  13  14  15
Affiliations
  • 1. State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • 2. The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • 3. University of Chinese Academy of Sciences, Beijing, China.
  • 4. Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
  • 5. State Key Laboratory of Drug Research, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • 6. University of Chinese Academy of Sciences, Beijing, China. [email protected].
  • 7. State Key Laboratory of Drug Research, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. [email protected].
  • 8. State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. [email protected].
  • 9. The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. [email protected].
  • 10. University of Chinese Academy of Sciences, Beijing, China. [email protected].
  • 11. Research Center for Deepsea Bioresources, Sanya, Hainan, China. [email protected].
  • 12. Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, China. [email protected].
  • 13. Research Center for Deepsea Bioresources, Sanya, Hainan, China. [email protected].
  • 14. Department of Chemistry, School of Science, The University of Tokyo, Tokyo, Japan. [email protected].
  • 15. Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, School of Pharmacy, Hainan Medical University, Haikou, Hainan, China. [email protected].
  • # Contributed equally.
PMID: 39019866 DOI: 10.1038/s41421-024-00700-0