Insights on the crosstalk among different cell death mechanisms

  • Cell Death Discov. 2025 Feb 10;11(1):56. doi: 10.1038/s41420-025-02328-9.
Georgette Eskander  1 ,  Sherihan G Abdelhamid  2 ,  Sara A Wahdan  3 ,  Sara M Radwan  4
Affiliations
  • 1. Postgraduate program, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
  • 2. Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
  • 3. Pharmacology and toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
  • 4. Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. [email protected].
PMID: 39929794 DOI: 10.1038/s41420-025-02328-9
Abstract

The phenomenon of cell death has garnered significant scientific attention in recent years, emerging as a pivotal area of research. Recently, novel modalities of cellular death and the intricate interplay between them have been unveiled, offering insights into the pathogenesis of various diseases. This comprehensive review delves into the intricate molecular mechanisms, inducers, and inhibitors of the underlying prevalent forms of cell death, including Apoptosis, Autophagy, Ferroptosis, Necroptosis, Mitophagy, and Pyroptosis. Moreover, it elucidates the crosstalk and interconnection among the key pathways or molecular entities associated with these pathways, thereby paving the way for the identification of novel therapeutic targets, disease management strategies, and drug repurposing.