Seven New Guanidine Derivatives and One New Hypoxanthine Derivative Isolated from the Scorpion Buthus martensii and Potential Anti-Neuroinflammatory Activity

  • J Nat Prod. 2025 Mar 28;88(3):821-829. doi: 10.1021/acs.jnatprod.5c00040.
Ke-Ming Li  1  2 ,  Wei-Fen Li  1 ,  Yong-Ming Yan  1 ,  Guangyi Yang  2 ,  Yong-Xian Cheng  1
Affiliations
  • 1. Guangdong Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Institute for Inheritance-Based Innovation of Chinese Medicine, Marshall Laboratory of Biomedical Engineering, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, People's Republic of China.
  • 2. Department of Pharmacy, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen 518104, People's Republic of China.
PMID: 40033829 DOI: 10.1021/acs.jnatprod.5c00040
Abstract

Twelve guanidine derivatives (1-12), including seven new compounds (martensiiagms A-G, 1-7), one new hypoxanthine derivative (martensiiagm H, 13), and 15 known compounds (14-28) were isolated from the whole body of Buthus martensii Karsch and identified by analysis of data. Subsequent biological evaluations revealed the anti-inflammatory activity of compound 1. It attenuates the neuroinflammation and oxidative stress levels prompted by lipopolysaccharide. This attenuation is accomplished by a specific action on mitochondria, which, in turn, caused a significant decrease in Reactive Oxygen Species and pro-inflammatory cytokines.

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