Salidroside attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis

  • J Asian Nat Prod Res. 2025 Apr 2:1-15. doi: 10.1080/10286020.2025.2481291.
Ling-Ling Zhen  1 ,  Ming-Tong Hou  2 ,  Sheng-Bao Wang  3
Affiliations
  • 1. The Second Hospital of Lanzhou University, Lanzhou730030, China.
  • 2. The Second Clinical Medical College of Lanzhou University, Lanzhou730030, China.
  • 3. Lanzhou University Second Hospital Emergency Center, Lanzhou730030, China.
PMID: 40171644 DOI: 10.1080/10286020.2025.2481291
Abstract

Salidroside is a traditional Chinese medicine with multiple pharmacological activities such as anti-inflammatory and antioxidant properties, while acute kidney injury (AKI) is a common sepsis-induced acute inflammatory response. Using transcriptomics combined with metabolomics, this study identifies arachidonic acid metabolism-associated Ferroptosis as an important mechanism for salidroside to improve sepsis-induced AKI (SI-AKI).

Keywords
Sepsis; acute kidney injury; arachidonic acid; ferroptosis; salidroside.
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